| (in credits order) | ||
| Alan Thicke | …. | Dr. Jason Seaver |
| Joanna Kerns | …. | Maggie Malone Seaver |
| Kirk Cameron | …. | Mike Seaver |
| Tracey Gold | …. | Carol Seaver |
| Jeremy Miller | …. | Ben Seaver |
| Ashley Johnson | …. | Chrissy Seaver (1990-1992) |
| Leonardo DiCaprio | …. | Luke Brower (1991-1992) 23 episodes |
| rest of cast listed alphabetically: | ||
| Jamie Abbott | …. | Stinky Sullivan (1989-1991) |
| Sam Anderson | …. | Mr. Dewitt (1986-1991) |
| Lisa Capps | …. | Debbie (1987-1988) |
| Kelsey Dohring | …. | Chrissy Seaver #1 (1988-1990) (shared) |
| Kirsten Dohring | …. | Chrissy Seaver #1 (1988-1990) (shared) |
| Rachel Jacobs | …. | Shelley (1987-1988) |
| Gordon Jump | …. | Ed Malone (1989-1991) |
| Bill Kirchenbauer | …. | Coach Graham Lubbock (1987-1988) |
| Andrew Koenig | …. | Richard “Boner” Stabone (1985-1989) |
| K.C. Martel | …. | Eddie (1985-1992) |
| Julie McCullough | …. | Julie Costello (1989-1990) |
| Betty McGuire | …. | Kate Malone (1989-1991) |
| Chelsea Noble | …. | Kate Macdonald (1989-1992) |
| Jane Powell | …. | Irma (1988-1990) |
| Robert Rockwell | …. | Wally (1988-1990) |